The effective concentration of a drug produces 50% of the maximal effect

What best describes EC50? The dose that is required to achieve 50% of the desired response in 50% of the population. The effective concentration of a drug that produces 50% of the minimum effect. The dose required to achieve 50% mortality from toxicity. The dose required to get 50% of the population reporting toxic side effects. The effective concentration of a drug produces 50% of the maximal effect.

Nortriptyline is metabolized by cytochrome P450 2D6. Which statement regarding homozygotes for inactive alleles of cytochrome P450 2D6 is most accurate? They have higher nortriptyline levels in the blood than heterozygotes. Homozygotes for inactive alleles of cytochrome P450 2D6 are not possible. They require a higher dose of nortriptyline to achieve the same concentration seen in patients with 2 active genes. They require a higher dose of nortriptyline to achieve the same concentration seen in heterozygotes.

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